Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function
نویسندگان
چکیده
منابع مشابه
Alzheimer's disease genetic risk variants beyond APOE ε4 predict mortality
INTRODUCTION We hypothesized that, like apolipoprotein E (APOE), other late-onset Alzheimer's disease (LOAD) genetic susceptibility loci predict mortality. METHODS We used a weighted genetic risk score (GRS) from 21 non-APOE LOAD risk variants to predict survival in the Adult Changes in Thought and the Health and Retirement Studies. We meta-analyzed hazard ratios and examined models adjusted ...
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OBJECTIVE To test for an association between the apolipoprotein E (APOE) ϵ4 allele and dementias with synucleinopathy. DESIGN Genetic case-control association study. SETTING Academic research. PATIENTS Autopsied subjects were classified into 5 categories: dementia with high-level Alzheimer disease (AD) neuropathologic changes (NCs) but without Lewy body disease (LBD) NCs (AD group; n=244)...
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The primary constituents of plaques (Aβ42/Aβ40) and neurofibrillary tangles (tau and phosphorylated forms of tau [ptau]) are the current leading diagnostic and prognostic cerebrospinal fluid (CSF) biomarkers for AD. In this study, we performed deep sequencing of APP, PSEN1, PSEN2, GRN, APOE and MAPT genes in individuals with extreme CSF Aβ42, tau, or ptau levels. One known pathogenic mutation (...
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OBJECTIVE The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here, we longitudinally test the effects of APOE ε4 genotype and age during progression from normal cognition to AD. METHODS Using data from 5381 cognitively normal older individuals and Cox proportional hazards mod...
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Xabier Elcoroaristizabal Martín, Manuel Fernández-Martínez*, Luis Galdos Alcelay, Fernando Gómez Busto, Maite Álvarez-Álvarez, Ana Molano Salazar A., Rocio Bereincua Gandarias , Sandra Inglés Borda. Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Ángeles Gómez Beldarraín, Josefa Moraza López, Nuria Ortiz Marqués, María Carrasco Zabaleta, Myriam Barandiarán Amillano, Marian M. de...
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ژورنال
عنوان ژورنال: Current Alzheimer Research
سال: 2016
ISSN: 1567-2050
DOI: 10.2174/1567205013666160401115127